Compositions and methods for treatment of the side-effects associated with administration of cancer chemotherapeutic agents

Patent No. 9,119,855

Issued: September 1, 2015
Filed: January 23, 2014

Inventor: Ford; John P. (Unadilla, NY)
Assignee: Asymmetric Therapeutics, LLC (Unadilla, NY)


A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine. In some embodiments, the slow release capsule also contains orotate. The systemic administration of a proton pump inhibitor decreases systemic absorption of orotate, and the systemic administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species. A method for prevention of oral stomatitis and a method for treatment of dysplastic tissue are also disclosed.

Reference to Related Applications

This is a continuation-in-part patent application of co-pending application Ser. No. 13/446,328, filed Apr. 13, 2012, now US Patent 8,653,090, entitled "COMPOSITIONS AND METHODS FOR TREATMENT OF THE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF CANCER CHEMOTHERAPEUTIC AGENTS", which is a continuation-in-part patent application of application Ser. No. 12/381,474, filed Mar. 12, 2009, entitled "COMPOSITION AND METHOD FOR TREATMENT OF THE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF CANCER CHEMOTHERAPEUTIC AGENTS", now abandoned, which claims one or more inventions which were disclosed in Provisional Application No. 61/069,031, filed Mar. 12, 2008, entitled "COMPOSITION AND METHOD FOR TREATMENT OF THE SIDE-EFFECTS ASSOCIATED WITH ADMINISTRATION OF CANCER CHEMOTHERAPEUTIC AGENTS". The benefit under 35 USC .sctn.119(e) of the United States provisional application is hereby claimed, and the aforementioned applications are hereby incorporated herein by reference.


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