Blood pressure regulating system by substituting native biological regulatory function

Patent No. 8,010,199

Issued: August 30, 2011
Filed: February 23, 2011

Inventors: Sunagawa; Kenji (Fukuoka, JP), Sugimachi; Masaru (Osaka, JP), Sato; Takayuki (Kochi, JP)
Assignee: National Cerebral and Cardiovascular Center (Osaka, JP) and Fujikin Inc. (Osaka, JP)


A blood pressure regulating system uses a native regulation rule to estimate at least one nerve activity in response to blood pressure changes, comprising at least one blood pressure sensing means which senses blood pressure and outputs a input blood pressure signal, a calculating means which receives the input blood pressure signal, calculates a transfer function by computing a Fourier transform of a normal blood pressure signal and a normal sympathetic nerve activity from normal cardiovascular system, calculates an impulse response by computing an inverse Fourier transform of the transfer function, calculates a sympathetic nerve stimulation signal using a convolution integral between the input blood pressure signal and the impulse response, and outputs the sympathetic nerve stimulation signal, and a stimulating means which receives the sympathetic nerve stimulation signal, and stimulates the sympathetic nerve innervating vascular beds based on the sympathetic nerve stimulation signal such that blood pressure is regulated.

Reference to Related Applications

This is a divisional patent application of copending application Ser. No. 12/103,786, filed Apr. 16, 2008, entitled "CARDIAC PACING SYSTEM, BLOOD PRESSURE REGULATING SYSTEM, AND CARDIAC DISEASE TREATMENT SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION", which is a divisional application of application Ser. No. 10/523,539, filed Feb. 3, 2005, entitled "MEDICAL TREATMENT SYSTEM BY SUBSTITUTING NATIVE BIOLOGICAL REGULATORY FUNCTION; CARDIAC PACING SYSTEM, BLOOD PRESSURE REGULATING SYSTEM, AND CARDIAC DISEASE TREATMENT SYSTEM BASED ON THE MEDICAL TREATMENT SYSTEM", now U.S. Pat. No. 7,835,791, issued Nov. 16, 2010. The aforementioned applications are hereby incorporated herein by reference.


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