Clonal cell lines derived from BTI-TN-5B1-4 

Patent No. 7,179,648

Issued: February 20, 2007
Filed: November 14, 2003
PCT Pub. No.: WO20/04/046318
PCT Pub. Date: June 03, 2004

Inventors: Granados; Robert R. (Ithaca, NY), Li; Guoxun (Qingdao, CN)
Assignee: Boyce Thompson Institute for Plant Research, Inc. (Ithaca, NY) 


Improved insect cell lines, two of which are designated H5CL-B and H5CL-F (both of which are derived from the parental cell line BTI-TN-5B1-4, ATCC CRL 10859), possess the properties of increased production of baculovirus particles, increased expression of foreign proteins using a baculovirus expression system, and increased resistance to cell culture stress, relative to the parental cell line.

REFERENCE TO RELATED APPLICATIONS

This application claims an invention which was disclosed in Provisional Application No. 60/426,535, filed Nov. 15, 2002, entitled "IMPROVED CLONAL CELL LINES DERIVED FROM BTI-TN-5B1-4". The benefit under 35 USC .sctn. 119(e) of the United States provisional application is hereby claimed, and the aforementioned application is hereby incorporated herein by reference in its entirety.

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