GP64-null baculoviruses pseudotyped with heterologous envelope proteins for gene therapy

Patent No. 6,858,205

Issued: February 22, 2005
Filed: June 20, 2003

Inventors: Blissard; Gary W. (Ithaca, NY); Mangor; Jodie T. (Ithaca, NY); Monsma; Scott A. (Madison, WI)
Assignee: Boyce Thompson Institute for Plant Research (Ithaca, NY)


A pseudotyped baculovirus comprises a deletion, inactivation or reduction from regulation of a baculovirus envelope protein gene, and is engineered to express an envelope protein from another virus or cell, or another protein or molecule that facilitates entry of the baculovirus into a non-host cell, or provided with a heterologous envelope protein or another protein or molecule that facilitates entry of the baculovirus into a non-host cell by other suitable means. Such baculoviruses can be used to efficiently deliver genes to mammalian cells or organisms, and such genes can be expressed either from the baculovirus genome, or integrated into the mammalian cell genome, and can be used for expression of proteins such that purification of secreted or other protein products does not require removal of contaminating baculovirus particles or baculovirus envelope proteins.

This is a continuation application of application Ser. No. 09/925,365, filed Aug. 9, 2001, now U.S. Pat. No. 6,607,912, entitled "GP64-NULL BACULOVIRUSES PSEUDOTYPED WITH HETEROLOGOUS ENVELOPE PROTEINS", which claims an invention which was disclosed in Provisional Application No. 60/224,612, filed Aug. 11, 2000, entitled "A GP64-NULL BACULOVIRUS PSEUDOTYPED WITH THE VESICULAR STOMATITIS VIRUS G PROTEIN THAT IS INFECTIOUS AND PROPAGATES IN Sf9 CELLS". 

ACKNOWLEDGMENT OF GOVERNMENT SUPPORT: This invention was made with Government support under Grant No. AI33657, awarded by the NIH. The government has certain rights in the invention.


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